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1.
Environ Sci Pollut Res Int ; 30(12): 33206-33228, 2023 Mar.
Article in English | MEDLINE | ID: covidwho-2289596

ABSTRACT

This paper presents the numerical results of particle propagation in open space, taking into account the temperature of the human body and the surface of the ground. And also, the settling of particles or droplets under the action of gravitational force and transport in the open air is taken into account, taking into account the temperature during the process of breathing and sneezing or coughing. The temperature of the body and the surface of the ground, different rates of particle emission from the mouth, such as breathing and coughing or sneezing, are numerically investigated. The effect of temperature, cross-inlet wind, and the velocity of particle ejection from a person's mouth on social distancing is being investigated using a numerical calculation. The variable temperature of the human body forms a thermal plume, which affects the increase in the trajectory of the particle propagation, taking into account the lateral air flow. The thermal plume affects the particles in the breathing zone and spreads the particles over long distances in the direction of the airflow. The result of this work shows that in open space, taking into account the temperature of the body and the surface of the ground, a 2-m social distance may be insufficient for the process of sneezing and social distance must be observed depending on the breathing mode.


Subject(s)
Human Body , Wind , Humans , Temperature , Particle Size , Physical Distancing , Respiratory Aerosols and Droplets , Sneezing
2.
Pensar Prát. (Online) ; 25Fev. 2022.
Article in Portuguese | WHO COVID, LILACS (Americas) | ID: covidwho-2292973

ABSTRACT

A pandemia da COVID-19 nos incitou a produzir uma reflexão a respeito dos conteúdos e modos de sugerir e orientar para a atividade física, haja vista ela não prevenir a infecção e, em ambientes fechados, favorecer a contaminação do vírus. De outra perspectiva, os corpos "das ruas" não se satisfazem com as instruções e respostas dos manuais e guias de atividade física. Nesse sentido, os profissionais de saúde precisam abrir os olhos, os corações e as mentes para a construção de movimentos de composição com as cidades e as lutas em defesa de todas as vidas e não se soltar ou se perder dos estudantes, potenciais cuidadores no futuro próximo. O que propomos para este ensaio é fazer pensar sobre o que nos passa enquanto docente e profissionais-pesquisadoras preocupadas e envolvidas com os processos de formação, especialmente no campo da saúde, a partir de ponderações teórico-conceituais sobre nossas experiências (AU).


The COVID-19 pandemic has prompted us to produce thought upon the content and modes of suggesting and directing physical activity, as it does not prevent infection, and, indoors, promotes contamination from the virus. From another perspective, the bodies of the "streets" are not satisfied with the instructions and answers of the manuals and physical activity guides. In this sense, health professionals need to open their eyes, hearts and minds to build compositional movements with the cities and struggles in defense of everybody's lives, holding onto and not getting lost from students, the potential carers in the near future. What we propose for this essay is to make us think about what happens to us as a professor and professionals-researches concerned and involved with the education processes, specially in the field of health, based on theoretical and conceptual considerations about our experiences (AU).


La pandemia COVID-19 nos incitó a reflexionar sobre los contenidos y formas de sugerir y orientar las actividades física, em vista de no prevenir la infección y, en ambientes cerrados, favorecer la contaminación por virus. Desde otra perspectiva, los cuerpos "de las calles" no están satisfechos con las instrucciones y respuestas de los manuales y guías de actividad física. En este sentido, los profesionales de la salud necesitan abrir los ojos, el corazón y la mente para construir movimientos de composición con ciudades y luchas en defensa de todas las vidas y no soltarse o perderse de los estudiantes, potenciales cuidadores en el futuro próximo.Lo que proponemos para este ensayo es hacernos reflexionar sobre lo que nos sucede como profesores-investigadores interesados e involucrados en los procesos de formación, especialmente en el campo de la salud, a partir de consideraciones teórico-conceptuales sobre nuestras experiencias (AU).


Subject(s)
Humans , Research Personnel , Exercise , Human Body , Delivery of Health Care , COVID-19 , Empathy , Movement
3.
Sensors (Basel) ; 22(19)2022 Oct 08.
Article in English | MEDLINE | ID: covidwho-2066356

ABSTRACT

Wearable sensors have traditionally been used to measure and monitor vital human signs for well-being and healthcare applications. However, there is a growing interest in using and deploying these technologies to facilitate teaching and learning, particularly in a higher education environment. The aim of this paper is therefore to systematically review the range of wearable devices that have been used for enhancing the teaching and delivery of engineering curricula in higher education. Moreover, we compare the advantages and disadvantages of these devices according to the location in which they are worn on the human body. According to our survey, wearable devices for enhanced learning have mainly been worn on the head (e.g., eyeglasses), wrist (e.g., watches) and chest (e.g., electrocardiogram patch). In fact, among those locations, head-worn devices enable better student engagement with the learning materials, improved student attention as well as higher spatial and visual awareness. We identify the research questions and discuss the research inclusion and exclusion criteria to present the challenges faced by researchers in implementing learning technologies for enhanced engineering education. Furthermore, we provide recommendations on using wearable devices to improve the teaching and learning of engineering courses in higher education.


Subject(s)
Wearable Electronic Devices , Human Body , Humans , Monitoring, Physiologic , Technology , Wrist
4.
Wiad Lek ; 75(6): 1544-1549, 2022.
Article in English | MEDLINE | ID: covidwho-1975857

ABSTRACT

OBJECTIVE: The aim: The aim of the study is to experimentally test the process of viral infection and determine the ways of its penetration into the human body. PATIENTS AND METHODS: Materials and methods: This experimental analysis is based on systematic research, published peer-reviewed articles, books, textbooks, monographs. It should also be noted that in order to identify some immunocompetent lymph node cells and the ability to visualize certain sites in the lymphoid nodes of Peyer's patches, where the initial processes are presented below, we resorted to sampling anatomical material. The study involved 10 adult albino rats weighing 200.0 ± 20.0 g. The search period covered the period from 2010 to 2021, but the experimental analysis contains some valuable data from previous years, as these literature sources have significant scientific value. RESULTS: Results: According to immunohistochemical analysis of the epithelium associated with the dome of the lymph nodes of the small intestine of white rats, the bulk was B-lymphocytes (about 47%) and T-lymphocytes (about 35%), while plasma cells, macrophages and dendritic cells accounted for approximately 5% for each of them. CONCLUSION: Conclusions: Рrocess of development of viral infection can be represented in the form of the following targeted steps: 1) massive invasion of viruses into the body; 2) the pathway of viruses to the intended target (target cells) is carried out by the blood flow; 3) аchieving the target by viruses and their penetration into target cells. Іn the pathogenesis of viral diseases, the role is played by the preparedness of the particular body, which directly depends on the functional state of its immune system, which determines the possibility, severity and outcome of the disease.


Subject(s)
Peyer's Patches , Virus Diseases , Adult , Human Body , Humans , Intestine, Small , Lymph Nodes , Peyer's Patches/metabolism
5.
Med Res Rev ; 42(6): 2126-2167, 2022 11.
Article in English | MEDLINE | ID: covidwho-1905913

ABSTRACT

The rising pandemic caused by a coronavirus, resulted in a scientific quest to discover some effective treatments against its etiologic agent, the severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2). This research represented a significant scientific landmark and resulted in many medical advances. However, efforts to understand the viral mechanism of action and how the human body machinery is subverted during the infection are still ongoing. Herein, we contributed to this field with this compilation of the roles of both viral and human enzymes in the context of SARS-CoV-2 infection. In this sense, this overview reports that proteases are vital for the infection to take place: from SARS-CoV-2 perspective, the main protease (Mpro ) and papain-like protease (PLpro ) are highlighted; from the human body, angiotensin-converting enzyme-2, transmembrane serine protease-2, and cathepsins (CatB/L) are pointed out. In addition, the influence of the virus on other enzymes is reported as the JAK/STAT pathway and the levels of lipase, enzymes from the cholesterol metabolism pathway, amylase, aspartate aminotransferase, alanine aminotransferase, lactate dehydrogenase, and glyceraldehyde 3-phosphate dehydrogenase are also be disturbed in SARS-CoV-2 infection. Finally, this paper discusses the importance of detailed enzymatic studies for future treatments against SARS-CoV-2, and how some issues related to the syndrome treatment can create opportunities in the biotechnological market of enzymes and the development of new drugs.


Subject(s)
COVID-19 Drug Treatment , Alanine Transaminase/pharmacology , Amylases/pharmacology , Angiotensins/pharmacology , Antiviral Agents/pharmacology , Antiviral Agents/therapeutic use , Aspartate Aminotransferases/pharmacology , Cathepsins/pharmacology , Cholesterol , Human Body , Humans , Janus Kinases/pharmacology , Lactate Dehydrogenases , Lipase/pharmacology , Papain/pharmacology , SARS-CoV-2 , STAT Transcription Factors/pharmacology , Serine Proteases/pharmacology , Signal Transduction
6.
Int J Mol Sci ; 23(8)2022 Apr 10.
Article in English | MEDLINE | ID: covidwho-1785750

ABSTRACT

INTRODUCTION AND PURPOSE OF THE STUDY: SARS-CoV-2 virus does not only affect the respiratory system. It may cause damage to many organ systems with long-term effects. The latest scientific reports inform that this virus leaves a long-term trace in the nervous, circulatory, respiratory, urinary and reproductive systems. It manifests itself in disturbances in the functioning of the organs of these systems, causing serious health problems. The aim of the study was to review the latest research into the long-term effects of COVID-19 and determine how common these symptoms are and who is most at risk. Based on a literature review using the electronic scientific databases of PubMed and Web of Science on the long-term effects of SARS-CoV-2 infection, 88 studies were included in the analysis. The information contained in the analyzed literature shows that the SARS-CoV-2 virus can cause multi-organ damage, causing a number of long-term negative health complications. CONCLUSIONS: There is evidence that the virus can cause long-term complications lasting more than six months. They mainly concern disturbances in the functioning of the nervous, circulatory and respiratory systems. However, these studies are small or short-lasting, and many are speculative.


Subject(s)
COVID-19 , SARS-CoV-2 , Human Body , Humans , Inflammation
7.
Sensors (Basel) ; 21(24)2021 Dec 15.
Article in English | MEDLINE | ID: covidwho-1572596

ABSTRACT

Life was once normal before the first announcement of COVID-19's first case in Wuhan, China, and what was slowly spreading became an overnight worldwide pandemic. Ever since the virus spread at the end of 2019, it has been morphing and rapidly adapting to human nature changes which cause difficult conundrums in the efforts of fighting it. Thus, researchers were steered to investigate the virus in order to contain the outbreak considering its novelty and there being no known cure. In contribution to that, this paper extensively reviewed, compared, and analyzed two main points; SARS-CoV-2 virus transmission in humans and detection methods of COVID-19 in the human body. SARS-CoV-2 human exchange transmission methods reviewed four modes of transmission which are Respiratory Transmission, Fecal-Oral Transmission, Ocular transmission, and Vertical Transmission. The latter point particularly sheds light on the latest discoveries and advancements in the aim of COVID-19 diagnosis and detection of SARS-CoV-2 virus associated with this disease in the human body. The methods in this review paper were classified into two categories which are RNA-based detection including RT-PCR, LAMP, CRISPR, and NGS and secondly, biosensors detection including, electrochemical biosensors, electronic biosensors, piezoelectric biosensors, and optical biosensors.


Subject(s)
Biosensing Techniques , COVID-19 , COVID-19 Testing , Human Body , Humans , SARS-CoV-2
8.
Front Immunol ; 12: 693938, 2021.
Article in English | MEDLINE | ID: covidwho-1523694

ABSTRACT

More than one and a half years have elapsed since the commencement of the coronavirus disease 2019 (COVID-19) pandemic, and the world is struggling to contain it. Being caused by a previously unknown virus, in the initial period, there had been an extreme paucity of knowledge about the disease mechanisms, which hampered preventive and therapeutic measures against COVID-19. In an endeavor to understand the pathogenic mechanisms, extensive experimental studies have been conducted across the globe involving cell culture-based experiments, human tissue organoids, and animal models, targeted to various aspects of the disease, viz., viral properties, tissue tropism and organ-specific pathogenesis, involvement of physiological systems, and the human immune response against the infection. The vastly accumulated scientific knowledge on all aspects of COVID-19 has currently changed the scenario from great despair to hope. Even though spectacular progress has been made in all of these aspects, multiple knowledge gaps are remaining that need to be addressed in future studies. Moreover, multiple severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants have emerged across the globe since the onset of the first COVID-19 wave, with seemingly greater transmissibility/virulence and immune escape capabilities than the wild-type strain. In this review, we narrate the progress made since the commencement of the pandemic regarding the knowledge on COVID-19 mechanisms in the human body, including virus-host interactions, pulmonary and other systemic manifestations, immunological dysregulations, complications, host-specific vulnerability, and long-term health consequences in the survivors. Additionally, we provide a brief review of the current evidence explaining molecular mechanisms imparting greater transmissibility and virulence and immune escape capabilities to the emerging SARS-CoV-2 variants.


Subject(s)
COVID-19/immunology , COVID-19/virology , Host Microbial Interactions/immunology , Animals , Human Body , Humans , Lung/immunology , Lung/virology , Pandemics/prevention & control , SARS-CoV-2/immunology , SARS-CoV-2/pathogenicity
9.
Anat Rec (Hoboken) ; 304(11): 2559-2565, 2021 11.
Article in English | MEDLINE | ID: covidwho-1274670

ABSTRACT

Traditional Chinese medicine (TCM) has a long history of serving the Chinese people's health since its birth, including playing an important role in treating and preventing COVID-19 in 2020. The fact that TCM has been used in China for thousands of years shows the value and reason why it must exist. Although TCM has been or is being questioned, there is no doubt about its importance in terms of efficacy. This article focuses on how TCM understands the human body in comparison with anatomy knowledge in western medicine and discusses the development and advances of TCM in terms of the body view and the theory innovation. The purpose is to let foreign scholars get better understanding of TCM from this perspective.


Subject(s)
COVID-19/therapy , Human Body , Medicine, Chinese Traditional/history , Medicine, Chinese Traditional/methods , Qi/history , COVID-19/epidemiology , Emotions/physiology , History, 19th Century , History, 20th Century , History, 21st Century , Humans , Medicine, Chinese Traditional/trends , Reference Books, Medical
10.
J Zhejiang Univ Sci B ; 22(4): 310-317, 2021 Apr 15.
Article in English | MEDLINE | ID: covidwho-1175474

ABSTRACT

Since December 2019, the novel coronavirus (severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)) has spread to many countries around the world, developing into a global pandemic with increasing numbers of deaths reported worldwide. To data, although some vaccines have been developed, there are no ideal drugs to treat novel coronavirus pneumonia (coronavirus disease 2019 (COVID-19)). By examining the structure of the coronavirus and briefly describing its possible pathogenesis based on recent autopsy reports conducted by various teams worldwide, this review analyzes the possible structural and functional changes of the human body upon infection with SARS-CoV-2. We observed that the most prominent pathological changes in COVID-19 patients are diffuse alveolar damage (DAD) of the lungs and microthrombus formation, resulting in an imbalance of the ventilation/perfusion ratio and respiratory failure. Although direct evidence of viral infection can also be found in other organs and tissues, the viral load is relatively small. The conclusion that the injuries of the extra-pulmonary organs are directly caused by the virus needs further investigation.


Subject(s)
COVID-19/pathology , Lung/pathology , COVID-19/physiopathology , Human Body , Humans , Immune Evasion , Lung/virology , Viral Load
11.
Sensors (Basel) ; 21(6)2021 Mar 17.
Article in English | MEDLINE | ID: covidwho-1143564

ABSTRACT

According to the Center for Disease Control and Prevention (CDC), the average human life expectancy is 78.8 years. Specifically, 3.2 million deaths are reported yearly due to heart disease, cancer, Alzheimer's disease, diabetes, and COVID-19. Diagnosing the disease is mandatory in the current way of living to avoid unfortunate deaths and maintain average life expectancy. CMOS image sensor (CIS) became a prominent technology in assisting the monitoring and clinical diagnosis devices to treat diseases in the medical domain. To address the significance of CMOS image 'sensors' usage in disease diagnosis systems, this paper focuses on the CIS incorporated disease diagnosis systems related to vital organs of the human body like the heart, lungs, brain, eyes, intestines, bones, skin, blood, and bacteria cells causing diseases. This literature survey's main objective is to evaluate the 'systems' capabilities and highlight the most potent ones with advantages, disadvantages, and accuracy, that are used in disease diagnosis. This systematic review used PRISMA workflow for study selection methodology, and the parameter-based evaluation is performed on disease diagnosis systems related to the human body's organs. The corresponding CIS models used in systems are mapped organ-wise, and the data collected over the last decade are tabulated.


Subject(s)
Diagnostic Imaging/instrumentation , Semiconductors , Human Body , Humans
12.
Int. j. morphol ; 39(1): 160-163, feb. 2021.
Article in English | WHO COVID, LILACS (Americas) | ID: covidwho-1058553

ABSTRACT

SUMMARY: Modern anatomy education is imbued with humanistic values which manifest primarily in the ethical acquisition of bodies for research and education, and respectful treatment of these bodies in anatomy laboratories. This humanistic approach is best embedded in the organisation of commemorative ceremonies for body donors. This paper presents experiences of preparation and implementation of a commemorative ceremony at Macquarie University, Sydney. Local cultural context and university infrastructure were considered when preparing the commemoration. It was decided that it will be introduced in stages, starting with a ceremony for anatomy students. Students were surveyed about the introduction of the ceremony and their attitudes about its format. The results of the survey influenced the format in which the commemoration was conducted. The commemoration was introduced in 2019, embedded in the first anatomy lecture. Such format was cost effective, caused little disturbance to a complex timetable and was aligned with learning outcomes and students' cultural preferences. It also enabled easy transition to the online modes of the delivery caused by the COVID-19 pandemic in Australia. In the next stage commemorative ceremony will be inclusive of donor family members as well as students.


RESUMEN: La educación en anatomía moderna está incentivada de valores humanistas que se manifiestan principalmente en la adquisición ética de cuerpos para la investigación y la educación, y en el trato respetuoso de estos cuerpos en los laboratorios de anatomía. Este enfoque humanista se integra mejor en la organización de ceremonias conmemorativas para donantes de cuerpos. Este documento presenta las experiencias de preparación e implementación de una ceremonia conmemorativa en la Universidad Macquarie, Sydney. Se tuvo en cuenta el contexto cultural local y la infraestructura universitaria al preparar la conmemoración. Se decidió que se presentará por etapas, comenzando con una ceremonia para estudiantes de anatomía. Los estudiantes fueron encuestados sobre la presentación de la ceremonia y sus actitudes sobre su formato. Los resultados de la encuesta influyeron en el formato en el que se llevó a cabo la conmemoración. La conmemoración se introdujo en 2019, como parte de la primera conferencia de anatomía. El formato era rentable, causaba pocas alteraciones en un horario complejo y estaba alineado con los resultados del aprendizaje y las preferencias culturales de los estudiantes. También permitió la transición a los modos en línea de la entrega causada por la pandemia de COVID-19 en Australia. En la siguiente etapa, la ceremonia conmemorativa incluirá a los miembros de la familia donante y a los estudiantes.


Subject(s)
Humans , Students, Medical , Tissue Donors , Human Body , Anatomy , Australia , Universities , Cadaver , Attitude , Surveys and Questionnaires
13.
J Bioeth Inq ; 17(4): 519-523, 2020 Dec.
Article in English | MEDLINE | ID: covidwho-728230

ABSTRACT

The lived experience of COVID-19 forcibly returns us to our bodies. This essay uses this (for most, sudden) return to embodiment to consider how our senses, as well as our "sense" of space, have been reoriented by this pandemic. It turns to certain strands within feminist philosophy that have questioned the privileged place vision has been accorded in the history of Western thought, as well as to mid-twentieth century phenomenologist Maurice Merleau-Ponty's aim to rediscover the world of perception by philosophically centring the body, as touchstones to put forth a phenomenology of contagion. Contagion makes us confront our phenomenological and embodied experience of tactility. This focus on tactility undermines the philosophical hierarchy of the senses that accords sight as the most "noble" of the senses in Western canonical thought. While COVID-19 results in us rediscovering our bodies through touch in a moment of fear and panic, this essay considers how this rediscovery may be harnessed for different, possibly more just, futures.


Subject(s)
COVID-19 , Interpersonal Relations , Perception , Philosophy , Touch , Body Image , COVID-19/psychology , COVID-19/transmission , Communicable Diseases , Fear , Human Body , Humans , Pandemics , Physical Distancing , SARS-CoV-2 , Sensation , Social Justice
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